A comprehensive dataset containing immune cell infiltration scores derived from CIBERSORT analysis of TCGA Stomach Adenocarcinoma (STAD) RNA-seq data. Includes detailed immune cell subtype proportions for each gastric cancer sample.
Usage
data(tcga_stad_sig)Format
A data frame with 375 rows (samples) and 464 variables:
ID – TCGA barcode
22 CIBERSORT immune-cell proportions (0–1 scale)
Immune-checkpoint and signature scores
Remaining columns – other deconvolution / signature outputs
Source
The Cancer Genome Atlas (TCGA) Research Network, processed with CIBERSORT https://www.cancer.gov/tcga https://cibersortx.stanford.edu/
References
Newman AM et al. Robust enumeration of cell subsets from tissue expression profiles. Nature Methods 12, 453-457 (2015). doi:10.1038/nmeth.3337
Thorsson V et al. The Immune Landscape of Cancer. Immunity 48, 812-830 (2018). doi:10.1016/j.immuni.2018.03.023
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513, 202-209 (2014). doi:10.1038/nature13480
Examples
data(tcga_stad_sig)
head(tcga_stad_sig)
#> ID B_cells_naive_CIBERSORT B_cells_memory_CIBERSORT
#> 1 TCGA-3M-AB46 0.01481047 0.00000000
#> 2 TCGA-3M-AB47 0.15891991 0.00000000
#> 3 TCGA-B7-5818 0.03229758 0.00000000
#> 4 TCGA-B7-A5TI 0.09144991 0.00000000
#> 5 TCGA-B7-A5TJ 0.02214811 0.01408048
#> 6 TCGA-B7-A5TK 0.02023961 0.00000000
#> Plasma_cells_CIBERSORT T_cells_CD8_CIBERSORT T_cells_CD4_naive_CIBERSORT
#> 1 0.004050517 0.04313768 0
#> 2 0.163357495 0.05557228 0
#> 3 0.000000000 0.19281089 0
#> 4 0.018021082 0.10148025 0
#> 5 0.000000000 0.03659444 0
#> 6 0.009667609 0.39414571 0
#> T_cells_CD4_memory_resting_CIBERSORT T_cells_CD4_memory_activated_CIBERSORT
#> 1 0.2848162 0.000000000
#> 2 0.3265441 0.008928501
#> 3 0.1049710 0.075517502
#> 4 0.1310717 0.044675105
#> 5 0.1656486 0.000000000
#> 6 0.0000000 0.257967418
#> T_cells_follicular_helper_CIBERSORT T_cells_regulatory_(Tregs)_CIBERSORT
#> 1 0.01560745 0.09322089
#> 2 0.00000000 0.06079957
#> 3 0.01745022 0.09561620
#> 4 0.05496906 0.07936586
#> 5 0.00000000 0.03022890
#> 6 0.01362455 0.01247031
#> T_cells_gamma_delta_CIBERSORT NK_cells_resting_CIBERSORT
#> 1 0 0.00000000
#> 2 0 0.01446237
#> 3 0 0.05889901
#> 4 0 0.01175564
#> 5 0 0.00000000
#> 6 0 0.00000000
#> NK_cells_activated_CIBERSORT Monocytes_CIBERSORT Macrophages_M0_CIBERSORT
#> 1 0.01737058 0.000000000 0.31923631
#> 2 0.00000000 0.000000000 0.07008833
#> 3 0.00000000 0.011160255 0.15037855
#> 4 0.00000000 0.000000000 0.12438510
#> 5 0.01605313 0.000000000 0.53395696
#> 6 0.00000000 0.005557542 0.01510891
#> Macrophages_M1_CIBERSORT Macrophages_M2_CIBERSORT
#> 1 0.07382949 0.06877707
#> 2 0.01885993 0.09073452
#> 3 0.09342079 0.13656912
#> 4 0.13346055 0.12740737
#> 5 0.03893579 0.12805517
#> 6 0.12251217 0.08711093
#> Dendritic_cells_resting_CIBERSORT Dendritic_cells_activated_CIBERSORT
#> 1 0.014680760 0.019325716
#> 2 0.012324930 0.010074881
#> 3 0.013276957 0.000000000
#> 4 0.030519049 0.005532904
#> 5 0.001462747 0.000000000
#> 6 0.015584638 0.024281872
#> Mast_cells_resting_CIBERSORT Mast_cells_activated_CIBERSORT
#> 1 0.00000000 0.025913254
#> 2 0.00000000 0.009333179
#> 3 0.00000000 0.013800077
#> 4 0.04590644 0.000000000
#> 5 0.01283568 0.000000000
#> 6 0.01681440 0.000000000
#> Eosinophils_CIBERSORT Neutrophils_CIBERSORT T_cells_MCPcounter
#> 1 0 0.005223618 1.008357
#> 2 0 0.000000000 2.018034
#> 3 0 0.003831820 2.260030
#> 4 0 0.000000000 1.728810
#> 5 0 0.000000000 1.074821
#> 6 0 0.004914319 3.050864
#> CD8_T_cells_MCPcounter Cytotoxic_lymphocytes_MCPcounter NK_cells_MCPcounter
#> 1 0.6759265 0.4878832 0.1209512
#> 2 1.3261442 1.2741564 0.6348687
#> 3 2.8097121 1.5946025 0.3867827
#> 4 1.3924681 1.1198864 0.3819530
#> 5 0.5198008 0.5614831 0.1012056
#> 6 4.8500824 3.0997579 1.3594507
#> B_lineage_MCPcounter Monocytic_lineage_MCPcounter
#> 1 1.195386 1.804003
#> 2 3.867724 2.283755
#> 3 1.622539 3.733155
#> 4 3.470448 3.182009
#> 5 1.535021 2.127953
#> 6 2.368274 4.337099
#> Myeloid_dendritic_cells_MCPcounter Neutrophils_MCPcounter
#> 1 0.8283189 1.528957
#> 2 1.5953098 1.612330
#> 3 1.9608801 1.887732
#> 4 1.3487403 1.367209
#> 5 1.1161453 1.538418
#> 6 1.9549814 1.727436
#> Endothelial_cells_MCPcounter Fibroblasts_MCPcounter aDC_xCell
#> 1 2.042321 5.924106 5.459613e-02
#> 2 3.624140 7.599288 2.277995e-01
#> 3 2.244634 6.447366 2.807839e-01
#> 4 3.700440 7.378179 2.291166e-01
#> 5 2.531191 6.149301 2.793215e-18
#> 6 3.008314 7.730924 4.922934e-01
#> Adipocytes_xCell Astrocytes_xCell B-cells_xCell Basophils_xCell
#> 1 0.000000000 0.1153534787 0.00000000 0.000000e+00
#> 2 0.002919704 0.0734321399 0.10187829 6.043823e-19
#> 3 0.004919741 0.0001320996 0.06496812 1.529934e-01
#> 4 0.011522134 0.0429371588 0.05386801 2.906072e-02
#> 5 0.002081328 0.0000000000 0.00000000 1.854643e-02
#> 6 0.004843433 0.1182583525 0.08495319 3.841721e-02
#> CD4+_memory_T-cells_xCell CD4+_naive_T-cells_xCell CD4+_T-cells_xCell
#> 1 0.004233951 2.771573e-18 1.987807e-19
#> 2 0.014939416 2.297559e-02 0.000000e+00
#> 3 0.002674317 3.173156e-02 5.555460e-19
#> 4 0.003069638 1.492658e-03 5.695283e-20
#> 5 0.001862031 0.000000e+00 1.858487e-19
#> 6 0.027963892 8.454613e-03 3.761374e-03
#> CD4+_Tcm_xCell CD4+_Tem_xCell CD8+_naive_T-cells_xCell CD8+_T-cells_xCell
#> 1 4.754938e-18 2.165525e-18 1.655896e-02 7.750578e-19
#> 2 0.000000e+00 1.619060e-02 0.000000e+00 1.728269e-02
#> 3 0.000000e+00 5.268910e-02 6.289963e-03 2.306013e-02
#> 4 0.000000e+00 1.955751e-18 2.627807e-19 7.666253e-21
#> 5 1.419190e-03 5.224171e-02 0.000000e+00 1.044442e-18
#> 6 0.000000e+00 0.000000e+00 1.404273e-02 1.618422e-01
#> CD8+_Tcm_xCell CD8+_Tem_xCell cDC_xCell Chondrocytes_xCell
#> 1 3.114355e-19 0.000000e+00 0.004369464 1.536763e-02
#> 2 5.308487e-02 0.000000e+00 0.037267966 1.646027e-01
#> 3 6.415769e-02 2.907605e-02 0.032713024 4.362729e-19
#> 4 8.201963e-03 3.500130e-19 0.015129573 3.007925e-02
#> 5 8.152916e-19 0.000000e+00 0.033577870 2.089459e-02
#> 6 2.468139e-01 1.063910e-01 0.184865108 4.462480e-02
#> Class-switched_memory_B-cells_xCell CLP_xCell CMP_xCell DC_xCell
#> 1 0.001025909 0.05808152 1.796613e-18 5.353093e-19
#> 2 0.042060309 0.02274494 0.000000e+00 8.462044e-03
#> 3 0.027881340 0.01625221 7.117845e-19 1.932121e-02
#> 4 0.030520235 0.02502416 1.084202e-19 1.008512e-02
#> 5 0.014690430 0.01281251 0.000000e+00 1.303550e-02
#> 6 0.060721399 0.03765766 0.000000e+00 7.600316e-02
#> Endothelial_cells_xCell Eosinophils_xCell Epithelial_cells_xCell
#> 1 0.00146803 0.000000e+00 0.4150087
#> 2 0.19657430 5.855865e-18 0.3061372
#> 3 0.02151950 0.000000e+00 0.3567121
#> 4 0.10864076 9.250263e-03 0.4271759
#> 5 0.02063793 1.615469e-02 0.4979105
#> 6 0.06158267 0.000000e+00 0.4083844
#> Erythrocytes_xCell Fibroblasts_xCell GMP_xCell Hepatocytes_xCell
#> 1 0.000000e+00 0.04929529 1.152106e-17 1.748751e-03
#> 2 9.286537e-20 0.16517515 1.695237e-18 0.000000e+00
#> 3 6.915697e-20 0.01505545 4.168570e-19 6.442467e-21
#> 4 3.041457e-04 0.01853755 4.091933e-03 8.869133e-03
#> 5 5.785283e-19 0.04403110 3.000329e-18 4.641516e-03
#> 6 0.000000e+00 0.14440482 2.401502e-02 6.954769e-04
#> HSC_xCell iDC_xCell Keratinocytes_xCell ly_Endothelial_cells_xCell
#> 1 0.10448036 0.00000000 0.05616660 0.002943256
#> 2 0.40198494 0.01977970 0.01676167 0.125513765
#> 3 0.03069725 0.08735302 0.03754721 0.009020764
#> 4 0.15515271 0.04734366 0.03161511 0.079367717
#> 5 0.06243578 0.29396530 0.05355211 0.017950758
#> 6 0.12966759 0.50834310 0.06883557 0.035521509
#> Macrophages_xCell Macrophages_M1_xCell Macrophages_M2_xCell Mast_cells_xCell
#> 1 0.000000000 3.565718e-21 0.003832225 6.500408e-20
#> 2 0.005705387 1.512258e-02 0.028759959 5.814541e-18
#> 3 0.108822432 4.793420e-02 0.083970542 0.000000e+00
#> 4 0.025341648 8.930150e-03 0.053196529 1.125717e-03
#> 5 0.007926572 8.654394e-03 0.017622798 3.883023e-03
#> 6 0.091095606 8.575380e-02 0.013792708 4.409007e-04
#> Megakaryocytes_xCell Melanocytes_xCell Memory_B-cells_xCell MEP_xCell
#> 1 0.000250399 0.0000000000 0.000000000 0.04595233
#> 2 0.016764920 0.0000000000 0.005335576 0.03438314
#> 3 0.000000000 0.0101401788 0.001337515 0.06869974
#> 4 0.004814387 0.0003501612 0.000000000 0.06224709
#> 5 0.001419074 0.0018348671 0.000000000 0.05402410
#> 6 0.005324486 0.0111804960 0.000000000 0.05099173
#> Mesangial_cells_xCell Monocytes_xCell MPP_xCell MSC_xCell
#> 1 0.102180219 0.000000e+00 9.591781e-18 0.000000e+00
#> 2 0.059653798 5.618461e-18 1.321997e-17 0.000000e+00
#> 3 0.014748265 5.881787e-03 1.612117e-18 3.125368e-01
#> 4 0.004673135 0.000000e+00 6.808835e-18 2.684289e-01
#> 5 0.049260728 7.225725e-18 0.000000e+00 4.072722e-18
#> 6 0.036104762 3.996675e-02 0.000000e+00 2.723980e-02
#> mv_Endothelial_cells_xCell Myocytes_xCell naive_B-cells_xCell Neurons_xCell
#> 1 0.00000000 0.001816992 2.607846e-19 0.0041392483
#> 2 0.10088700 0.005246438 0.000000e+00 0.0059096208
#> 3 0.03150160 0.000000000 1.119805e-19 0.0003102051
#> 4 0.05958711 0.002006949 0.000000e+00 0.0007921645
#> 5 0.01394197 0.000000000 2.102213e-18 0.0017957479
#> 6 0.03185165 0.004676401 1.888720e-18 0.0034353211
#> Neutrophils_xCell NK_cells_xCell NKT_xCell Osteoblast_xCell pDC_xCell
#> 1 0.000000e+00 0.000000e+00 0.009095393 0.000000e+00 0.0007180042
#> 2 0.000000e+00 0.000000e+00 0.088823079 0.000000e+00 0.0000000000
#> 3 0.000000e+00 0.000000e+00 0.080466635 1.560807e-02 0.0813006899
#> 4 2.419849e-20 6.247384e-18 0.027117036 1.338765e-18 0.0147578337
#> 5 9.372464e-19 0.000000e+00 0.037407737 0.000000e+00 0.0026152202
#> 6 1.008000e-05 5.328579e-02 0.058794974 2.890996e-19 0.1372267091
#> Pericytes_xCell Plasma_cells_xCell Platelets_xCell Preadipocytes_xCell
#> 1 0.004665095 0.01560623 2.986661e-18 9.912420e-19
#> 2 0.017957469 0.06426971 0.000000e+00 0.000000e+00
#> 3 0.075087346 0.01490837 7.030535e-19 2.543178e-19
#> 4 0.095133736 0.03772877 2.044710e-18 3.015437e-19
#> 5 0.040402427 0.01375101 5.491503e-19 2.728557e-20
#> 6 0.051494328 0.02364988 0.000000e+00 2.795602e-18
#> pro_B-cells_xCell Sebocytes_xCell Skeletal_muscle_xCell Smooth_muscle_xCell
#> 1 6.985125e-03 0.03482024 1.632135e-18 0.22969650
#> 2 0.000000e+00 0.01186757 4.557150e-18 0.37838693
#> 3 2.150721e-02 0.02266954 0.000000e+00 0.06361922
#> 4 4.845746e-19 0.01226987 0.000000e+00 0.28084124
#> 5 9.890306e-20 0.02668249 0.000000e+00 0.28811641
#> 6 2.655780e-18 0.01818280 0.000000e+00 0.35613133
#> Tgd_cells_xCell Th1_cells_xCell Th2_cells_xCell Tregs_xCell
#> 1 1.015623e-18 0.09413447 0.113464270 3.124311e-18
#> 2 5.570771e-20 0.02523189 0.059507128 2.038065e-18
#> 3 5.164825e-18 0.20098841 0.119730314 2.743638e-03
#> 4 1.226604e-17 0.08344046 0.084507333 0.000000e+00
#> 5 4.737247e-18 0.07442995 0.009723067 6.563539e-20
#> 6 1.670090e-17 0.22404319 0.246221296 4.047646e-02
#> ImmuneScore_xCell StromaScore_xCell MicroenvironmentScore_xCell Bcells_EPIC
#> 1 1.049435e-18 0.02538166 0.02538166 0.01186530
#> 2 8.888560e-02 0.18233458 0.27122018 0.05885556
#> 3 1.480358e-01 0.02074734 0.16878313 0.02260847
#> 4 6.644717e-02 0.06935022 0.13579739 0.04626292
#> 5 2.733320e-02 0.03337518 0.06070838 0.01596059
#> 6 3.409060e-01 0.10541546 0.44632147 0.02633957
#> CAFs_EPIC CD4_Tcells_EPIC CD8_Tcells_EPIC Endothelial_EPIC Macrophages_EPIC
#> 1 0.02281602 0.1597232 0.05215585 0.1038049 0.008210656
#> 2 0.02588570 0.2202835 0.07311529 0.2082408 0.010294394
#> 3 0.02056021 0.1631332 0.10990559 0.1236952 0.014595447
#> 4 0.02319369 0.1586950 0.06801268 0.1705856 0.010500367
#> 5 0.02001080 0.1782781 0.05412233 0.1437885 0.008978729
#> 6 0.02155437 0.2049444 0.17866755 0.1563829 0.013925580
#> NKcells_EPIC otherCells_EPIC StromalScore_estimate ImmuneScore_estimate
#> 1 1.363014e-10 0.6414241 -286.2160 164.8031
#> 2 1.072503e-09 0.4033247 990.9170 1226.5895
#> 3 6.221647e-09 0.5455018 -110.5759 1761.8033
#> 4 1.635763e-10 0.5227498 397.5037 676.2542
#> 5 5.526187e-10 0.5788610 -516.6395 116.9989
#> 6 7.957043e-09 0.3981856 993.7424 2458.1702
#> ESTIMATEScore_estimate TumorPurity_estimate B_cells_quantiseq
#> 1 -121.4128 0.8325145 0.009856277
#> 2 2217.5065 0.5974400 0.020391186
#> 3 1651.2274 0.6619581 0.008971498
#> 4 1073.7579 0.7230407 0.021020080
#> 5 -399.6405 0.8544398 0.010174975
#> 6 3451.9126 0.4431490 0.006834955
#> Macrophages_M1_quantiseq Macrophages_M2_quantiseq Monocytes_quantiseq
#> 1 0.035357640 0.005669912 0
#> 2 0.016461205 0.038270623 0
#> 3 0.094306272 0.029865226 0
#> 4 0.034998574 0.035204562 0
#> 5 0.008395831 0.021016855 0
#> 6 0.096149423 0.073988618 0
#> Neutrophils_quantiseq NK_cells_quantiseq T_cells_CD4_quantiseq
#> 1 0.002861924 0.005134811 0.000000000
#> 2 0.019117012 0.016015838 0.003100943
#> 3 0.003866517 0.021595936 0.000000000
#> 4 0.063112358 0.011416493 0.000000000
#> 5 0.025229511 0.011954941 0.000000000
#> 6 0.045324473 0.000000000 0.000000000
#> T_cells_CD8_quantiseq Tregs_quantiseq Dendritic_cells_quantiseq
#> 1 0.0021537897 0.01590725 0.015454632
#> 2 0.0031781854 0.02254274 0.000478614
#> 3 0.0189801023 0.01757416 0.000000000
#> 4 0.0031828511 0.02588249 0.000000000
#> 5 0.0007738596 0.01644640 0.007972638
#> 6 0.1179098365 0.03479589 0.000000000
#> Other_quantiseq B_cell_TIMER T_cell_CD4_TIMER T_cell_CD8_TIMER
#> 1 0.9076038 0.05505488 0.1125324 0.1136379
#> 2 0.8604436 0.10363477 0.1482578 0.1637782
#> 3 0.8048403 0.06464305 0.1319967 0.1792306
#> 4 0.8051826 0.08911428 0.1329312 0.1618534
#> 5 0.8980350 0.07051458 0.1298607 0.1168160
#> 6 0.6249968 0.07760934 0.1390543 0.2438372
#> Neutrophil_TIMER Macrophage_TIMER DC_TIMER MHC_IPS EC_IPS SC_IPS
#> 1 0.09987219 0.03542312 0.4192694 3.016440 0.7475634 -0.6289439
#> 2 0.10184639 0.05926243 0.4657841 3.141802 1.0257594 -0.9377661
#> 3 0.13128817 0.05771622 0.5303474 3.557041 1.0883194 -1.3654921
#> 4 0.11461254 0.06008004 0.4848943 2.788159 0.9958343 -1.0333771
#> 5 0.09123476 0.04733987 0.4443594 3.159959 0.7067192 -0.8027516
#> 6 0.15278781 0.04922721 0.5696544 3.975626 1.4404193 -1.5762808
#> CP_IPS AZ_IPS IPS_IPS CD_8_T_effector DDR APM
#> 1 0.11501267 3.250072 10 -1.37082918 1.52932392 -0.3691970
#> 2 -0.02256518 3.207230 10 -1.50940808 -2.59656461 -0.2816170
#> 3 -0.57581969 2.704049 9 2.53609581 0.09606526 0.6852633
#> 4 -0.11874202 2.631874 9 -0.01203826 0.67323052 -1.2279819
#> 5 0.12696900 3.190896 10 -2.23729684 -0.38117637 0.2957044
#> 6 -1.16515341 2.674612 9 5.57762089 -0.74207011 1.7070561
#> Immune_Checkpoint CellCycle_Reg Pan_F_TBRs Histones EMT1 EMT2
#> 1 -1.7577164 1.3013385 -0.6715007 0.09265741 1.23916149 -0.6836216
#> 2 -0.7179886 -1.1180711 0.8815172 -0.65221830 0.03387956 0.7493675
#> 3 0.9528213 -1.1693611 -0.2959240 1.27811196 -2.60697653 -0.1114483
#> 4 -0.3538363 0.3279732 -0.8771967 0.25731439 -0.51554478 0.2071909
#> 5 -1.6681298 -0.3670248 0.3099037 -0.24623573 1.50490448 -0.5044492
#> 6 2.4960629 -0.8699155 2.5525980 -0.24707853 -2.89140454 1.2494793
#> EMT3 WNT_target FGFR3_related Cell_cycle Mismatch_Repair
#> 1 -0.05020175 -1.1373525 -0.40576891 1.3514167 1.42923251
#> 2 0.84130878 -0.0500345 -0.58056720 -2.1985880 -1.15383701
#> 3 -0.85786751 -0.3699317 0.07056333 0.9954845 0.62454225
#> 4 0.30706307 -0.1915579 1.02136439 0.7536018 0.41955907
#> 5 -0.47993662 0.2778230 0.51366768 -0.1294777 -0.01343549
#> 6 0.93843961 0.4147650 -1.11413098 -0.5237433 -0.06592700
#> Homologous_recombination Nucleotide_excision_repair DNA_replication
#> 1 0.6390930 1.4827347 1.56195961
#> 2 -1.3446988 -1.1921500 -1.65202228
#> 3 0.4760785 0.8123925 1.31235004
#> 4 0.6305554 0.3006752 0.43574363
#> 5 -0.4207181 -0.1667614 -0.24253899
#> 6 -0.3210915 0.1031562 -0.04732597
#> Base_excision_repair TMEscoreA_CIR TMEscoreB_CIR CD8_Rooney_et_al
#> 1 1.1913645 -2.502340 -3.886500 -1.9390164
#> 2 -0.9921065 -2.326732 5.954428 -1.0136405
#> 3 0.5754819 2.918105 -6.912650 1.4822404
#> 4 0.2869589 -1.138562 -0.292653 -0.3702344
#> 5 -0.1217690 -4.027658 -2.011842 -2.1142099
#> 6 -0.2144669 9.502608 5.655672 3.9339582
#> B_cells_Rooney_et_al Treg_Rooney_et_al Macrophages_Rooney_et_al
#> 1 -2.0916534 -0.48296390 -0.92271393
#> 2 1.2189544 -0.26390540 -0.89269824
#> 3 -0.9829173 0.10362401 0.82081151
#> 4 0.3480072 0.05108743 -0.10870144
#> 5 -1.5378871 -0.42590381 -0.08558872
#> 6 -0.3684596 1.58667024 1.05855088
#> Neutrophils_Rooney_et_al NK_cells_Rooney_et_al pDCs_Rooney_et_al
#> 1 -1.5808179 -0.29060478 -1.2016810
#> 2 0.2407446 0.48674247 -0.2188821
#> 3 -0.1928486 0.02001352 1.0238391
#> 4 -0.3329526 -0.02224068 0.1682774
#> 5 -1.6228876 -0.31198692 -0.9319491
#> 6 1.1235967 0.55720222 2.1698786
#> MHC_Class_I_Rooney_et_al Co_stimulation_APC_Rooney_et_al
#> 1 -0.4681896 0.4892341
#> 2 -0.2874600 0.8573845
#> 3 0.5567429 0.5038637
#> 4 -0.8954895 -0.4405928
#> 5 0.1318488 -0.7688580
#> 6 1.3197750 1.2745475
#> Co_stimulation_T_cell_Rooney_et_al Co_inhibition_APC_Rooney_et_al
#> 1 -1.7413434 -1.1252849
#> 2 0.4421479 0.2708199
#> 3 0.3882795 0.1840474
#> 4 -0.2393019 -0.1981103
#> 5 -1.9003877 -0.9249330
#> 6 1.5368760 1.6381824
#> Co_inhibition_T_cell_Rooney_et_al Type_I_IFN_Reponse_Rooney_et_al
#> 1 -1.7612545 -0.07038974
#> 2 -0.4762626 -0.61750397
#> 3 0.9394759 -1.36532606
#> 4 -0.4434159 -1.21587405
#> 5 -1.5646362 -2.33829448
#> 6 2.7194193 3.24780443
#> Type_II_IFN_Reponse_Rooney_et_al Cytolytic_Activity_Rooney_et_al MHC_Class_I
#> 1 -1.20494621 -1.2380747 -0.6630777
#> 2 1.09560407 -0.3093616 -0.5696251
#> 3 -1.02919777 0.8230395 0.8155263
#> 4 0.03503031 -0.2682789 -1.5243608
#> 5 -0.42481244 -1.4167525 -0.1668697
#> 6 0.48518064 2.4541395 1.3809422
#> MHC_Class_II T_cell_inflamed_GEP_Ayers_et_al IFNG_signature_Ayers_et_al
#> 1 -1.0989360 -2.6413852 -0.4975268
#> 2 -1.6509838 -0.7502348 -1.2520955
#> 3 1.6681645 1.8789329 1.9839811
#> 4 -0.9083739 -0.6647958 -0.2693307
#> 5 -2.7447953 -3.6318881 -1.8005057
#> 6 4.1611767 6.4607306 5.4367124
#> MDSC_Wang_et_al GPAGs PPAGs HLA_signature_gene
#> 1 -1.9668073 -0.6233382 0.49616523 -10.1667759
#> 2 -1.3327313 1.1386773 -1.45306834 0.7296065
#> 3 1.1806338 -0.7436677 -0.27909645 3.8597620
#> 4 -0.5731199 0.1969477 0.55188247 -1.1732596
#> 5 -3.1870487 -1.5277651 -0.07107112 -9.8554611
#> 6 2.7304954 0.7828167 2.11539595 11.7673448
#> B_cells_Danaher_et_al CD8_T_cells_Danaher_et_al Cytotoxic_cells_Danaher_et_al
#> 1 -1.3927584 -1.2666643 -2.2347204
#> 2 1.2716707 -0.3130214 -1.4089553
#> 3 -1.3548015 0.6108115 2.1040398
#> 4 0.3202618 -0.4200625 -0.3562991
#> 5 -1.1703301 -1.2842346 -2.2852782
#> 6 -0.7654560 2.1420946 5.0317514
#> DC_Danaher_et_al Exhausted_CD8_Danaher_et_al Macrophages_Danaher_et_al
#> 1 -1.47599578 -1.3145727 -1.62758215
#> 2 -0.86150463 -0.2645965 -0.20417365
#> 3 0.43774280 0.3154956 0.56652691
#> 4 0.08969879 -0.4391829 -0.01521981
#> 5 -1.18949462 -1.0556010 -0.96095242
#> 6 1.65850880 2.0147476 1.12914245
#> Mast_cells_Danaher_et_al Neutrophils_Danaher_et_al
#> 1 -1.8057768 -1.3336525
#> 2 -1.3209557 -1.6530449
#> 3 -0.9942743 0.3873280
#> 4 0.8719435 -0.7927935
#> 5 -1.0408525 -1.3943849
#> 6 0.9830108 0.3455236
#> NK_CD56dim_cells_Danaher_et_al NK_cells_Danaher_et_al T_cells_Danaher_et_al
#> 1 -0.4871751 0.06140739 -1.5039598
#> 2 -0.2790193 0.27489658 0.7611246
#> 3 0.5926927 0.91594569 0.5919070
#> 4 -0.1803499 -0.23873896 -0.3924256
#> 5 -0.4664319 -0.90289847 -1.6566334
#> 6 0.8139913 1.09089730 2.7862225
#> TIP_Release_of_cancer_cell_antigens TIP_Cancer_antigen_presentation_1
#> 1 -0.5721616 -1.8529424
#> 2 -1.7456433 -0.8475633
#> 3 0.5578675 0.3518655
#> 4 0.1530192 -0.9773532
#> 5 -1.7232329 -1.8435191
#> 6 2.2655021 1.5042437
#> TIP_Cancer_antigen_presentation_2 TIP_Priming_and_activation_1
#> 1 -0.3600218 -3.0828966
#> 2 -0.3034552 0.6001772
#> 3 -0.1480654 1.7764229
#> 4 -0.2070187 -0.5238976
#> 5 -0.3442948 -3.5248450
#> 6 0.2262627 4.6344104
#> TIP_Priming_and_activation_2 TIP_Trafficking_of_immune_cells_to_tumors
#> 1 -2.083459 -3.8996666
#> 2 -0.281506 0.4255130
#> 3 1.362570 0.8269720
#> 4 -0.487457 0.1273632
#> 5 -1.887654 -2.7923629
#> 6 2.928330 5.2710730
#> TIP_Infiltration_of_immune_cells_into_tumors_1
#> 1 -1.53612296
#> 2 -0.52201716
#> 3 0.44250693
#> 4 0.02192257
#> 5 -0.62752046
#> 6 1.04833526
#> TIP_Infiltration_of_immune_cells_into_tumors_2
#> 1 -0.17630259
#> 2 -1.08046466
#> 3 0.82393257
#> 4 -0.06044894
#> 5 -0.37507872
#> 6 0.61075247
#> TIP_Recognition_of_cancer_cells_by_T_cells_1
#> 1 -1.5983350
#> 2 0.3891578
#> 3 0.6971877
#> 4 -0.2177470
#> 5 -1.8743546
#> 6 2.4277614
#> TIP_Recognition_of_cancer_cells_by_T_cells_2 TIP_Killing_of_cancer_cells_1
#> 1 -1.24021587 -1.3945084
#> 2 -0.09091643 -1.2051069
#> 3 0.32979923 1.4439602
#> 4 -0.23064692 -0.1065073
#> 5 -1.20492872 -1.3877350
#> 6 1.73757395 3.2478441
#> TIP_Killing_of_cancer_cells_2 TLS_Nature TMEscoreA_plus TMEscoreB_plus
#> 1 -1.3682906 -1.8035589 -1.7524520 -1.5367930
#> 2 -0.6145478 1.3765470 -2.5123852 1.4949327
#> 3 0.9690403 0.2322224 2.7134696 -1.9892657
#> 4 -0.7895413 0.1719754 -0.5929183 -0.2920369
#> 5 -1.7137139 -0.5012321 -3.0021857 -0.7445221
#> 6 3.9594795 -0.3114219 8.6156918 1.3553472
#> B_cells_Bindea_et_al T_cells_Bindea_et_al T_helper_cells_Bindea_et_al
#> 1 -3.186642 -2.0690576 -1.3702475
#> 2 3.015188 1.0589179 0.1955685
#> 3 -1.647434 0.6732940 0.2834269
#> 4 1.190536 -0.3625607 0.7110417
#> 5 -2.791759 -2.4854199 -0.5494905
#> 6 0.118889 3.4387289 1.0819612
#> Tcm_Bindea_et_al Tem_Bindea_et_al Th1_cells_Bindea_et_al
#> 1 -1.6165310 -0.45620895 -0.4827538
#> 2 0.6224554 0.74855017 1.4629149
#> 3 -1.0378463 -0.06121643 -1.9146378
#> 4 -0.4438421 0.08361523 0.6676923
#> 5 -0.6024228 -0.94459631 0.6552308
#> 6 0.6887723 1.05542938 0.2376237
#> Th2_cells_Bindea_et_al TFH_Bindea_et_al Th17_cells_Bindea_et_al
#> 1 1.90014486 -2.0336610 0.5409817
#> 2 -1.06610952 0.0896051 -0.8425293
#> 3 0.88723575 0.3065582 0.6343211
#> 4 0.40124480 0.6967847 -0.8835826
#> 5 -0.07343554 -2.5998788 0.7284978
#> 6 -0.79942250 2.1506437 -0.8644498
#> CD8_T_cells_Bindea_et_al Tgd_Bindea_et_al Cytotoxic_cells_Bindea_et_al
#> 1 -1.97450367 -0.08627291 -2.0077073
#> 2 0.39191845 0.50699394 -0.8644311
#> 3 0.67589907 -0.46169365 1.6282711
#> 4 -0.04865235 0.12774641 -0.5094481
#> 5 -1.60564485 -0.30280679 -2.1911237
#> 6 2.72758874 0.24589389 4.2671112
#> NK_cells_Bindea_et_al NK_CD56dim_cells_Bindea_et_al DC_Bindea_et_al
#> 1 -1.3954653 1.0033217 -1.6928062
#> 2 0.8817344 -0.5321826 -0.5948681
#> 3 -0.6167636 -1.4874749 0.2335520
#> 4 0.1039500 1.2324944 0.2725577
#> 5 -0.7488801 1.0422975 -1.4279719
#> 6 0.7506572 -2.1374614 2.1121880
#> iDC_Bindea_et_al aDC_Bindea_et_al Eosinophils_Bindea_et_al
#> 1 -1.8549722 -0.7024331 -2.0820204
#> 2 1.0527928 -0.6722959 1.9099722
#> 3 -0.4818288 0.3071185 -1.8004890
#> 4 -0.2421440 -0.3992923 -0.2189508
#> 5 -1.6303635 -1.3506890 -0.1332295
#> 6 0.6986133 1.3808898 1.6325425
#> Macrophages_Bindea_et_al Mast_cells_Bindea_et_al Neutrophils_Bindea_et_al
#> 1 -2.4670366 -2.5160381 -1.8339791
#> 2 0.2640171 -0.4670766 -1.6812518
#> 3 2.1736324 -1.8980008 0.4126321
#> 4 0.3770203 0.6977823 -0.2367302
#> 5 -0.9338276 -1.4681618 -2.1978295
#> 6 2.1541115 1.3159252 0.3237516
#> SW480_cancer_cells_Bindea_et_al Normal_mucosa_Bindea_et_al
#> 1 -0.9455525 -1.3963763
#> 2 -2.1214755 2.3723891
#> 3 0.7646011 -1.5137370
#> 4 -0.3906177 -0.1422416
#> 5 0.9127274 -0.6287419
#> 6 1.7664535 2.9761627
#> Lymph_vessels_Bindea_et_al Antigen_Processing_and_Presentation_Li_et_al
#> 1 -0.18214191 -3.183865
#> 2 0.68337784 -1.555405
#> 3 -0.01407469 2.800394
#> 4 0.32869374 -1.760384
#> 5 -0.39172601 -3.241718
#> 6 0.49763238 5.769652
#> Antimicrobials_Li_et_al BCR_Signaling_Pathway_Li_et_al Chemokines_Li_et_al
#> 1 -7.03870804 -3.1944851 -5.18518015
#> 2 0.68380661 1.4755255 0.07479606
#> 3 1.10852425 -1.1006597 -0.59682785
#> 4 -0.03746409 0.3088486 0.01146014
#> 5 -4.13252268 -2.1058567 -2.21956286
#> 6 7.30340189 0.2747424 4.31039831
#> Chemokine_Receptors_Li_et_al Cytokines_Li_et_al Cytokine_Receptors_Li_et_al
#> 1 -2.4433069 -4.8956459 -4.5065629
#> 2 0.2584526 3.4756228 2.5117608
#> 3 0.5413430 -3.4440537 -0.8346030
#> 4 -0.3116294 0.2573679 -0.3888116
#> 5 -2.6269166 -2.2820663 -4.4515738
#> 6 2.2852942 4.3453484 3.3366982
#> Interferons_Li_et_al Interferon_Receptor_Li_et_al Interleukins_Li_et_al
#> 1 -0.4748119 0.23267453 -0.8813586
#> 2 -0.2832738 -0.08928787 -1.3020890
#> 3 0.6382024 -0.54457900 -0.0206884
#> 4 -0.2405901 0.01462042 -0.5953450
#> 5 -0.4561302 -0.17938070 -1.3923383
#> 6 2.1698910 0.83621707 -0.2429825
#> Interleukins_Receptor_Li_et_al Natural_Killer_Cell_Cytotoxicity_Li_et_al
#> 1 -2.3385943 -3.6724125
#> 2 0.1134742 -0.9173396
#> 3 0.8130548 2.3393435
#> 4 -0.3220267 -1.0737881
#> 5 -1.8379278 -2.9341637
#> 6 1.9610130 5.2365923
#> TCR_signaling_Pathway_Li_et_al TGFb_Family_Member_Li_et_al
#> 1 -3.61067346 -2.4896515
#> 2 -0.04456279 0.3397321
#> 3 1.10440751 -0.3458105
#> 4 -0.84636206 -0.2717425
#> 5 -3.20931022 0.5925148
#> 6 3.77571744 0.5321220
#> TGFb_Family_Member_Receptor_Li_et_al TNF_Family_Members_Li_et_al
#> 1 -1.1941224 0.1199289
#> 2 0.7096633 0.7604426
#> 3 -0.8212743 1.3393394
#> 4 -0.1697929 0.5980871
#> 5 -0.4100139 -1.2666919
#> 6 0.9559559 1.3981020
#> TNF_Family_Members_Receptors_Li_et_al T_cell_accumulation_Peng_et_al
#> 1 -1.0929919131 -0.80242277
#> 2 0.6007949343 0.36883833
#> 3 0.0002283112 -0.85320968
#> 4 -0.0796444849 0.33578959
#> 5 -1.1529251935 -0.43004728
#> 6 0.1411028893 -0.09973613
#> T_cell_exhaustion_Peng_et_al T_cell_regulatory_Peng_et_al
#> 1 -1.1628971 -1.07166254
#> 2 -0.3173681 -0.31790490
#> 3 0.3337975 0.02564971
#> 4 -0.1409009 -0.45614734
#> 5 -2.8572321 -2.23736948
#> 6 1.9964199 3.86974789
#> ICB_resistance_Peng_et_al MDSC_Peng_et_al TAM_Peng_et_al CAF_Peng_et_al
#> 1 -3.179124 1.5016871 -2.55203605 0.5556785
#> 2 -1.366339 -2.3385990 1.18421555 5.0838680
#> 3 1.963038 0.9902356 -0.67852265 -0.6681014
#> 4 -1.557100 -1.2500482 0.03650967 2.8773958
#> 5 -3.560169 0.6642526 -2.37275546 -1.0146886
#> 6 5.035416 -1.1035116 2.56104992 2.9760997
#> T_cell_probe_Jeschke_et_al MeTIL_Jeschke_et_al Cardiolipin_Metabolism
#> 1 -2.1842911 0.1743267 0.7196985
#> 2 0.6418177 -0.8284883 1.0269316
#> 3 0.6865899 0.1720380 -0.7712321
#> 4 -0.2619777 -0.2359001 -0.1977495
#> 5 -1.6922187 0.3029957 0.6960396
#> 6 1.6633166 0.2054168 -1.1571526
#> Cardiolipin_Biosynthesis Cholesterol_Biosynthesis Citric_Acid_Cycle
#> 1 0.17928872 0.5663080 0.273322610
#> 2 -0.08066776 -2.3318358 -0.001272307
#> 3 -0.14892981 1.5421940 -0.689057542
#> 4 0.13151763 -0.3705362 0.495498603
#> 5 0.59272881 1.8346542 0.787413919
#> 6 0.03710760 -1.2712719 -1.358018528
#> Cyclooxygenase_Arachidonic_Acid_Metabolism Prostaglandin_Biosynthesis
#> 1 -0.06472205 -1.60213141
#> 2 -0.56969786 0.69517610
#> 3 -0.99091342 0.35445109
#> 4 0.70869894 -0.07671466
#> 5 -1.33517216 -0.33185819
#> 6 1.10026279 -0.38820616
#> Purine_Biosynthesis Pyrimidine_Biosynthesis Dopamine_Biosynthesis
#> 1 0.27706743 -0.1698082 0.1615349
#> 2 -0.03867629 -0.2275076 0.2295014
#> 3 -0.26047609 0.1053787 0.5607774
#> 4 0.33399430 0.3783093 1.1040841
#> 5 0.40572513 0.5971187 0.5618463
#> 6 0.15261485 -0.6349518 -0.8468508
#> Epinephrine_Biosynthesis Norepinephrine_Biosynthesis Fatty_Acid_Degradation
#> 1 0.1559042 0.1652103 -1.08289059
#> 2 0.2229875 0.2287205 0.06868885
#> 3 0.5473134 0.5601606 0.13559885
#> 4 1.1026560 1.1042282 2.67813774
#> 5 0.5690086 0.5627805 -0.67703348
#> 6 -0.8573929 -0.8439209 -2.50160993
#> Fatty_Acid_Elongation Fatty_Acid_Biosynthesis Folate_One_Carbon_Metabolism
#> 1 0.2354470 0.001582669 2.2498662
#> 2 -0.2041995 0.283470782 -1.2482136
#> 3 0.8601904 0.327154785 -1.4345814
#> 4 0.4106495 -0.549988546 -0.8705571
#> 5 0.7112034 0.158919210 -0.8084768
#> 6 -0.4520103 0.133895796 -1.1815296
#> Folate_biosynthesis Gluconeogenesis Glycolysis Glycogen_Biosynthesis
#> 1 4.923042763 0.7867080 0.8087378 0.12287022
#> 2 -0.969183564 -0.3992010 -0.3659408 -0.06987352
#> 3 -1.103031181 -1.4770865 -1.4885779 -0.74574624
#> 4 -0.162451342 2.9469730 3.0284358 0.33049501
#> 5 0.009749772 0.1943241 0.1957634 -0.63749684
#> 6 0.147442773 -3.3273770 -3.3589565 0.36518667
#> Glycogen_Degradation Heme_Biosynthesis Hexosamine_Biosynthesis
#> 1 0.04546728 -0.51349366 0.60527786
#> 2 -0.01160068 -0.08789085 0.60680956
#> 3 -1.05817747 0.55715264 -0.48050391
#> 4 0.02970467 0.13178063 0.13020317
#> 5 -0.86532056 0.24075230 0.02689908
#> 6 0.29866139 -0.17424330 -0.51892424
#> Homocysteine_Biosynthesis Remethylation Transsulfuration
#> 1 -0.39086462 0.03072175 0.103440809
#> 2 0.86005322 -0.77387138 0.950562852
#> 3 -0.31449848 -0.06500971 0.396683912
#> 4 0.08297327 0.04280390 0.047517438
#> 5 -0.60841207 0.38465892 0.001111472
#> 6 1.01479908 -1.13899609 0.159488810
#> Ketone_Biosynthesis_and_Metabolism Kynurenine_Metabolism Methionine_Cycle
#> 1 0.7311907 -0.6629416 0.3369167
#> 2 -0.0108373 -0.3993060 -1.6258462
#> 3 -2.0960472 0.6150602 0.5277671
#> 4 2.4324241 -0.4021472 -0.1506582
#> 5 1.4242886 -0.9520386 0.3179599
#> 6 -2.0337567 3.5113690 -1.4775444
#> Pentose_Phosphate Nicotinamide_Adenine_Metabolism ADP_Ribosylation
#> 1 1.9644447 0.1727235 -1.3010146
#> 2 0.1642273 1.2466562 0.1612291
#> 3 -1.5123639 1.8541276 -0.3766011
#> 4 1.3992871 1.5082314 -0.8355845
#> 5 0.5857677 0.5472688 -1.6533991
#> 6 -2.1447182 -1.4196681 1.9786150
#> Nicotinamide_Adenine_Dinucleotide_Biosynthesis
#> 1 0.42454667
#> 2 0.02926824
#> 3 -1.02281428
#> 4 1.09163504
#> 5 1.29588322
#> 6 -0.84455807
#> Nicotinate_and_Nicotinamide_Metabolism Sirtuin_Nicotinamide_Metabolism
#> 1 0.28901517 0.1567103
#> 2 0.07696776 -0.3024959
#> 3 -1.16533497 0.6983066
#> 4 1.02915656 0.1465489
#> 5 0.81934594 0.3599644
#> 6 -0.79970464 -0.1737765
#> Polyamine_Biosynthesis Prostanoid_Biosynthesis Pyruvate_Metabolism
#> 1 -0.1681563 -1.39674920 1.0986293
#> 2 -0.2728127 0.59240894 -0.8314549
#> 3 0.2117324 -0.84908699 2.1951962
#> 4 -0.1419462 0.05262935 -0.9671452
#> 5 0.2266966 -0.36583055 0.4414511
#> 6 0.6285211 1.12370433 0.4470557
#> Retinoic_Acid_Metabolism Retinoid_Metabolism Retinol_Metabolism
#> 1 -0.32815510 0.01523212 -0.631834826
#> 2 -0.10372784 -0.11525370 -1.065561953
#> 3 -1.50526271 -0.48407716 0.524193004
#> 4 -0.14361633 0.07969237 4.892923603
#> 5 -0.06821077 -0.54141878 -0.004215562
#> 6 -0.02875877 0.31322104 -1.673828398
#> Steroid_Hormone_Metabolism Aldosterone_Biosynthesis Cortisol_Biosynthesis
#> 1 -0.05076516 -0.007695097 -0.4107447
#> 2 0.47705781 -0.071651302 -0.3400733
#> 3 1.29371283 0.300076369 -0.1420980
#> 4 3.20240280 0.396310780 -0.2033787
#> 5 1.86163849 -0.184223713 -0.1526592
#> 6 -0.61333760 -0.077323498 -0.3076603
#> Estradiol_Biosynthesis Testosterone_Biosynthesis Urea_Cycle Vitamin_K
#> 1 0.4251366 -0.70431951 -1.3218026 0.079978483
#> 2 1.3097883 0.03052804 0.3249421 0.185602476
#> 3 -0.3803959 -1.13258861 -0.7814497 0.647483888
#> 4 1.5578373 0.80238969 2.4971842 0.005520626
#> 5 -0.3931863 0.39487652 -0.5471714 -0.042245597
#> 6 1.6920389 0.06974099 -1.4117940 0.180011796
#> Pentose_and_Glucuronate_Interconversions Fructose_and_Mannose_Metabolism
#> 1 -1.3629693 0.1841543
#> 2 -0.5601682 0.4454267
#> 3 1.0359940 -0.4329959
#> 4 3.7517478 2.5900662
#> 5 1.3817510 1.0429994
#> 6 -0.8037245 -1.4259324
#> Galactose_Metabolism Ascorbate_and_Aldrate_Metabolism
#> 1 -0.3761657 -0.7082867
#> 2 0.3749529 -0.8959219
#> 3 -0.2620686 0.8567009
#> 4 2.6996792 3.3643595
#> 5 1.1632575 1.3546283
#> 6 -0.5631332 -0.8461012
#> Starch_and_Suctose_Metabolism Amino_Sugar_and_Nucleotide_Sugar_Metabolism
#> 1 1.3000228 0.4787556
#> 2 0.5865965 0.5515941
#> 3 -1.0501469 0.2402910
#> 4 1.9151642 0.6162933
#> 5 1.1307764 0.9960962
#> 6 -1.1406609 -0.7443625
#> Glyoxylate_and_Dicarboxylate_Metabolism Propanoate_Metabolism
#> 1 -0.64068727 0.1704753
#> 2 -0.70381576 0.2252462
#> 3 -0.03527402 -0.6768377
#> 4 -0.07887079 0.4059453
#> 5 -0.17582731 1.3732843
#> 6 -0.69076408 -1.4759487
#> Butanoate_Metabolism Inositol_Phosphate_Metabolism Oxidative_Phosphorylation
#> 1 0.6041702 -1.6942133 2.6913134
#> 2 0.1108519 0.2666991 2.7701886
#> 3 -1.9357822 -0.3208879 2.7891990
#> 4 2.7210925 -0.9284110 1.7381470
#> 5 1.4966850 -0.9137677 0.8829125
#> 6 -2.1935219 0.5554907 0.7698601
#> Nitrogen_Metabolism Sulfur_Metabolism Steroid_Biosynthesis
#> 1 -1.1053304 -0.2755909 0.95928347
#> 2 -0.9496925 0.8130463 -0.41609727
#> 3 1.2971947 1.0265251 -0.09909852
#> 4 2.1119130 0.9899004 -0.62105667
#> 5 -2.1264507 0.7004613 2.45200166
#> 6 -1.7707388 0.1012463 -1.15853628
#> Primary_Bile_Acid_Biosynthesis Steroid_Hormone_Biosynthesis
#> 1 0.2024541 -0.03318752
#> 2 1.2398003 0.48558200
#> 3 -1.1725359 1.28697336
#> 4 -0.6411832 3.19737020
#> 5 0.7203226 1.81041778
#> 6 -0.5749807 -0.60787630
#> Glycerolipid_Metabolism Glycerophospholipid_Metabolism Ether_Lipid_Metabolism
#> 1 -1.9253652 -0.2837234 -0.4047413
#> 2 -0.9373393 -0.4154491 -0.5319129
#> 3 -1.4240120 -2.5855053 -2.9002227
#> 4 0.7814985 -2.1002695 -2.0614764
#> 5 2.0806602 -1.5180939 -1.5091155
#> 6 -1.7161858 3.3213803 3.2764399
#> Shingolipid_Metabolism Arachidonic_Acid_Metabolism Linoleic_Acid_Metabolism
#> 1 -0.9830746 -2.0455952 -0.3049325
#> 2 -0.5127544 0.1215636 -0.4327134
#> 3 0.6471777 -1.3853467 -2.9615915
#> 4 0.3544337 -1.4801059 -2.1032799
#> 5 1.1691470 -1.9275982 -1.3216338
#> 6 -1.2137066 2.4158999 3.1087297
#> alpha_Linoleic_Acid_Metabolism Biosynthesis_of_Unsaturated_Fatty_Acids
#> 1 -0.3303001 0.53974895
#> 2 -0.4527917 -0.44522913
#> 3 -2.8537178 -0.06383619
#> 4 -2.0669746 -0.30650654
#> 5 -1.4391666 -0.99110423
#> 6 3.2004682 0.24327217
#> Purine_Metabolism Pyrimidine_Metabolism
#> 1 1.9782138 1.1214024
#> 2 -1.8048920 -1.2539695
#> 3 2.0479252 1.6803567
#> 4 0.4548042 1.0327680
#> 5 1.2706897 -0.2278412
#> 6 -1.5027720 -0.3969471
#> Alanine_Aspartate_and_Glutamate_Metabolism
#> 1 -1.05578168
#> 2 -0.05772685
#> 3 -0.75945390
#> 4 2.99779980
#> 5 -1.00883191
#> 6 -1.38296021
#> Glycine_Serine_and_Threonine_Metabolism Cysteine_and_Methionine_Metabolism
#> 1 -1.1891103 0.2907136
#> 2 0.8587329 -0.3703672
#> 3 -1.1975713 1.1561317
#> 4 -0.3100590 0.6539856
#> 5 -0.4867949 0.9240440
#> 6 0.2597781 -0.4448162
#> Valine_Leucine_and_Isoleucine_Degradation
#> 1 0.3229494
#> 2 0.3280135
#> 3 -2.2655841
#> 4 2.5432263
#> 5 1.6719860
#> 6 -2.3801655
#> Valine_Leucine_and_Isoleucine_Biosynthesis Lysine_Degradation
#> 1 -0.26337556 -0.9157674
#> 2 -0.12854769 0.5161956
#> 3 0.64642172 -1.2564879
#> 4 0.19190863 -0.6198896
#> 5 -0.60419219 -0.4009276
#> 6 0.08361814 0.1326039
#> Arginine_Biosynthesis Arginine_and_Proline_Metabolism Histidine_Metabolism
#> 1 -1.4431678 0.7315435 -0.2098592
#> 2 1.4187183 1.4296218 -0.9762819
#> 3 -0.7973655 0.2861187 -0.1353115
#> 4 2.0345858 0.4243502 1.3524093
#> 5 -0.4536614 1.0422854 1.3504112
#> 6 -0.8198606 -0.1053214 -1.4894958
#> Tyrosine_Metabolism Phenylalanine_Metabolism Tryptophan_Metabolism
#> 1 -1.3654975 -1.59349220 0.9142161
#> 2 -0.2718443 -0.03659799 -0.6688987
#> 3 -0.2789517 -1.73337723 0.7120824
#> 4 2.6006083 -0.47934916 1.0770328
#> 5 -0.7835834 -0.65630398 1.8656585
#> 6 -2.1622358 0.23804432 -2.6460614
#> Phenylalanine_Tyrosine_and_Tryptophan_Biosynthesis Beta_Alanine_Metabolism
#> 1 1.0715651 -0.3121492
#> 2 -0.8313891 -1.9024820
#> 3 1.0798826 -0.1631697
#> 4 -0.3225271 0.9747739
#> 5 -0.8846193 0.7685253
#> 6 1.0468052 -0.7799512
#> Taurine_and_Hypotaurine_Metabolism Selenocompound_Metabolism
#> 1 0.4237544 -0.5731220
#> 2 1.2675542 -1.2407493
#> 3 -1.0786679 0.4355351
#> 4 -0.4235326 0.1547612
#> 5 1.0099835 0.1250369
#> 6 -1.8420834 -0.8173393
#> D_Glutamine_and_D_Glutamate_Metabolism Glutathione_Metabolism
#> 1 -0.64239336 0.2464843
#> 2 0.07678262 1.7132922
#> 3 0.22055691 -0.5235911
#> 4 0.11632678 2.1984753
#> 5 0.08915499 0.5746485
#> 6 0.05193504 -1.9086913
#> N_Glycan_Biosynthesis Mucin_Type_O_Glycan_Biosynthesis
#> 1 0.7425014 -0.5323942
#> 2 -1.0084800 0.3579622
#> 3 1.2948938 -1.4449991
#> 4 0.7864304 -0.1680423
#> 5 0.6132345 0.8801406
#> 6 -0.5784128 -0.2721236
#> Other_Types_of_O_Glycan_Biosynthesis Glycosaminoglycan_Biosynthesis
#> 1 -1.01830264 -2.4310116
#> 2 0.51190081 0.2967435
#> 3 -1.15407435 -0.8475843
#> 4 -0.31538612 0.6164402
#> 5 -0.47185615 -0.9717461
#> 6 0.07101804 0.2303062
#> Glycosaminoglycan_Degradation Glycosphosphatidylinositol
#> 1 -1.1353098 0.3719327
#> 2 -0.2926041 -0.8317751
#> 3 -0.1539628 0.4464391
#> 4 0.5950179 0.7151608
#> 5 -0.6030791 0.3884634
#> 6 0.1680914 -0.7803778
#> Glycosphingolipid_Biosynthesis Other_Glycan_Degradation Thiamine_Metabolism
#> 1 1.2606860 1.0417609 0.01781998
#> 2 1.1474318 -0.5507023 0.44530052
#> 3 0.3318697 -0.6310961 0.25759382
#> 4 0.4433456 -0.2410096 0.29531958
#> 5 1.4804967 -0.8105324 0.08006634
#> 6 -1.7732545 -0.0999025 0.07166104
#> Riboflavin_Metabolism Vitamin_B6_Metabolism Pantothenate_and_CoA_Biosynthesis
#> 1 0.1115724 0.4904767 1.6034380
#> 2 -0.2229875 -0.7234028 0.9489444
#> 3 0.5509538 0.8072126 -0.1964229
#> 4 0.7213455 0.5754475 1.2922526
#> 5 0.1591167 0.3586384 0.3267371
#> 6 -0.4243153 0.7644977 0.2035211
#> Biotin_Metabolism Lipoic_Acid_Metabolism Porphyrin_and_Chlorophyll_Metabolism
#> 1 0.015482513 0.27891931 -0.6530712
#> 2 -0.262954490 -0.17082271 -0.7500235
#> 3 -0.009869669 0.46196272 0.8690815
#> 4 0.042913937 0.24639534 3.4607708
#> 5 -0.167133710 -0.30838307 1.3896100
#> 6 -0.072565293 -0.07911203 -0.8707095
#> Ubiquinone_and_other_Terpenoid_Quinone_Biosynthesis
#> 1 0.1599173
#> 2 -0.3039356
#> 3 -0.1374509
#> 4 0.1434501
#> 5 0.6416321
#> 6 -0.4509804
#> Terpenoid_Backbone_Biosynthesis Caffiene_Metabolism
#> 1 0.85225981 0.69250408
#> 2 -0.00995634 1.64530289
#> 3 -2.03251890 -1.04928373
#> 4 2.45268350 0.06875841
#> 5 1.38107116 0.59553200
#> 6 -1.99972600 0.06099134
#> Neomycin_Kanamysin_and_Gentamicin_Biosynthesis
#> 1 -0.2201925
#> 2 0.2992020
#> 3 0.5302733
#> 4 0.4868488
#> 5 0.9456730
#> 6 0.4755842
#> Metabolism_of_Xenobiotics_by_Cytochrome_P450
#> 1 -0.5766458
#> 2 -1.6721627
#> 3 0.5478353
#> 4 3.9354320
#> 5 1.1067548
#> 6 -2.5447724
#> Drug_Metabolism_by_Cytochrome_P450 Drug_Metabolism_by_other_enzymes
#> 1 -0.5198912 -0.196283766
#> 2 -1.5098971 -0.153057896
#> 3 0.5919243 -0.008608925
#> 4 3.9288988 2.492069153
#> 5 0.7236942 1.661743433
#> 6 -2.5253872 -1.035348139
#> Nature_metabolism_Hypoxia Winter_hypoxia_signature Hu_hypoxia_signature
#> 1 -0.55416390 0.5963940 -1.4412711
#> 2 -0.78878142 -1.4145140 -0.9833938
#> 3 1.31993711 1.0400331 -1.4072491
#> 4 -0.19024181 -1.8998558 -0.4618776
#> 5 0.13904634 -0.7267675 -1.5505942
#> 6 0.06686291 -1.0741464 0.1330176
#> Molecular_Cancer_m6A MT_exosome Positive_regulation_of_exosomal_secretion
#> 1 0.08345999 -0.04221502 0.01953396
#> 2 -0.50215489 0.18906416 -0.38014875
#> 3 -0.44089177 -0.78930492 0.22566106
#> 4 0.10531093 0.04073695 0.22550743
#> 5 -0.29997287 -0.81478596 1.26107599
#> 6 -0.34229244 0.40037857 -0.92337345
#> Ferroptosis EV_Cell_2020 HALLMARK_ADIPOGENESIS HALLMARK_ALLOGRAFT_REJECTION
#> 1 -0.9384568 -1.5195948 0.3852436 0.2767765
#> 2 -0.1636537 0.7450249 0.4152516 0.3280813
#> 3 -1.0745498 -0.7832991 0.3870400 0.3530950
#> 4 0.1925525 0.4128628 0.4095310 0.3241504
#> 5 0.9311072 -0.7424201 0.4034037 0.2792960
#> 6 -0.8620934 1.5434534 0.3965509 0.3900258
#> HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANGIOGENESIS HALLMARK_APICAL_JUNCTION
#> 1 0.3849984 0.3544372 0.3066231
#> 2 0.4064006 0.3609078 0.3435999
#> 3 0.3786529 0.3524334 0.3231713
#> 4 0.4061448 0.3768589 0.3459572
#> 5 0.3933194 0.3604090 0.3419964
#> 6 0.4100539 0.3847367 0.3568663
#> HALLMARK_APICAL_SURFACE HALLMARK_APOPTOSIS HALLMARK_BILE_ACID_METABOLISM
#> 1 0.2563168 0.3825708 0.2458545
#> 2 0.2648920 0.4027275 0.2721093
#> 3 0.2890364 0.4036695 0.2557543
#> 4 0.2867092 0.4074327 0.2903015
#> 5 0.2518748 0.3817068 0.2733582
#> 6 0.3024790 0.4170706 0.2545683
#> HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_COAGULATION HALLMARK_COMPLEMENT
#> 1 0.4078328 0.2914105 0.3219301
#> 2 0.3803202 0.3101545 0.3448156
#> 3 0.3984949 0.2933739 0.3478903
#> 4 0.4077884 0.3284264 0.3501227
#> 5 0.4123468 0.3116854 0.3230356
#> 6 0.3958230 0.3346976 0.3713304
#> HALLMARK_DNA_REPAIR HALLMARK_E2F_TARGETS
#> 1 0.4167082 0.4402130
#> 2 0.4040985 0.3975091
#> 3 0.4223714 0.4237263
#> 4 0.4183347 0.4225058
#> 5 0.4110109 0.4100677
#> 6 0.4140294 0.4124426
#> HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_ESTROGEN_RESPONSE_EARLY
#> 1 0.3823349 0.3262654
#> 2 0.4163924 0.3490701
#> 3 0.3797214 0.3363359
#> 4 0.4185090 0.3561286
#> 5 0.3753788 0.3560551
#> 6 0.4208950 0.3514051
#> HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_FATTY_ACID_METABOLISM
#> 1 0.3468806 0.3653240
#> 2 0.3511255 0.3813077
#> 3 0.3451369 0.3698349
#> 4 0.3657551 0.3862490
#> 5 0.3649358 0.3816411
#> 6 0.3636795 0.3566172
#> HALLMARK_G2M_CHECKPOINT HALLMARK_GLYCOLYSIS HALLMARK_HEDGEHOG_SIGNALING
#> 1 0.4271982 0.3738069 0.2429580
#> 2 0.3947265 0.3792092 0.2985232
#> 3 0.4181890 0.3727768 0.2623483
#> 4 0.4146368 0.3866525 0.2931916
#> 5 0.4096197 0.3801816 0.2748259
#> 6 0.4084339 0.3689829 0.2883122
#> HALLMARK_HEME_METABOLISM HALLMARK_HYPOXIA HALLMARK_IL2_STAT5_SIGNALING
#> 1 0.3011517 0.3468699 0.3267632
#> 2 0.3222143 0.3663848 0.3561644
#> 3 0.3272936 0.3602327 0.3513653
#> 4 0.3282795 0.3701949 0.3523926
#> 5 0.3248223 0.3501472 0.3306594
#> 6 0.3221393 0.3688533 0.3817837
#> HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_INFLAMMATORY_RESPONSE
#> 1 0.3424558 0.2751517
#> 2 0.3534681 0.3014022
#> 3 0.3746757 0.3338088
#> 4 0.3503939 0.3203777
#> 5 0.3190636 0.2744917
#> 6 0.3980148 0.3555070
#> HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE
#> 1 0.4159912 0.3704779
#> 2 0.4170756 0.3930850
#> 3 0.4217877 0.4069239
#> 4 0.3844025 0.3709134
#> 5 0.3871969 0.3516569
#> 6 0.4776647 0.4564640
#> HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_UP
#> 1 0.07546127 0.3035045
#> 2 0.09070068 0.3333323
#> 3 0.09252444 0.3191365
#> 4 0.11174615 0.3358271
#> 5 0.10843820 0.3078465
#> 6 0.11216040 0.3587673
#> HALLMARK_MITOTIC_SPINDLE HALLMARK_MTORC1_SIGNALING HALLMARK_MYC_TARGETS_V1
#> 1 0.3837103 0.4314066 0.4878507
#> 2 0.3897663 0.4242139 0.4801551
#> 3 0.3902711 0.4412462 0.4834085
#> 4 0.3975542 0.4363994 0.4802974
#> 5 0.3978045 0.4329798 0.4793671
#> 6 0.3930692 0.4394715 0.4854639
#> HALLMARK_MYC_TARGETS_V2 HALLMARK_MYOGENESIS HALLMARK_NOTCH_SIGNALING
#> 1 0.4210013 0.2371768 0.3965075
#> 2 0.4186680 0.2786640 0.4245018
#> 3 0.4316781 0.2497410 0.4146122
#> 4 0.4256718 0.2791835 0.4287169
#> 5 0.4338258 0.2737053 0.4164742
#> 6 0.4169528 0.2857535 0.4033061
#> HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_P53_PATHWAY
#> 1 0.4565758 0.3801685
#> 2 0.4733845 0.3891089
#> 3 0.4623192 0.3974920
#> 4 0.4705058 0.4023819
#> 5 0.4655565 0.3952527
#> 6 0.4590689 0.4011130
#> HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PEROXISOME
#> 1 0.1225817 0.3467652
#> 2 0.1790448 0.3647890
#> 3 0.1665338 0.3562257
#> 4 0.1629845 0.3637011
#> 5 0.1802117 0.3578954
#> 6 0.1695491 0.3522554
#> HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PROTEIN_SECRETION
#> 1 0.3698332 0.4242377
#> 2 0.3746594 0.4276628
#> 3 0.3736768 0.4127578
#> 4 0.3810211 0.4316921
#> 5 0.3694226 0.4264874
#> 6 0.3817450 0.4325856
#> HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY HALLMARK_SPERMATOGENESIS
#> 1 0.4031670 0.1405140
#> 2 0.4222244 0.1264101
#> 3 0.4455504 0.1328666
#> 4 0.4219009 0.1370892
#> 5 0.4210225 0.1214898
#> 6 0.4274244 0.1554726
#> HALLMARK_TGF_BETA_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
#> 1 0.4139929 0.3916331
#> 2 0.4426871 0.3892229
#> 3 0.4223397 0.4120596
#> 4 0.4233932 0.4100374
#> 5 0.4216217 0.3707969
#> 6 0.4417310 0.4314499
#> HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UV_RESPONSE_DN
#> 1 0.4263015 0.3568853
#> 2 0.4281554 0.3876783
#> 3 0.4406831 0.3490858
#> 4 0.4385104 0.3771374
#> 5 0.4306581 0.3629098
#> 6 0.4398904 0.3828701
#> HALLMARK_UV_RESPONSE_UP HALLMARK_WNT_BETA_CATENIN_SIGNALING
#> 1 0.3669097 0.3233245
#> 2 0.3706817 0.3582367
#> 3 0.3760893 0.3285884
#> 4 0.3868174 0.3485954
#> 5 0.3684657 0.3678428
#> 6 0.3811559 0.3312915
#> HALLMARK_XENOBIOTIC_METABOLISM GO_CELLULAR_RESPONSE_TO_FATTY_ACID
#> 1 0.2974215 0.2776676
#> 2 0.3187496 0.3318828
#> 3 0.3172750 0.2842821
#> 4 0.3390077 0.3292297
#> 5 0.3194946 0.2983561
#> 6 0.3145922 0.3053644
#> GO_CHOLESTEROL_EFFLUX GO_FATTY_ACID_BETA_OXIDATION
#> 1 0.1914171 0.3148461
#> 2 0.1863452 0.3523165
#> 3 0.1950400 0.3361803
#> 4 0.2305607 0.3569925
#> 5 0.2218549 0.3446685
#> 6 0.2642048 0.3268241
#> GO_FATTY_ACID_BIOSYNTHETIC_PROCESS GO_FATTY_ACID_CATABOLIC_PROCESS
#> 1 0.2620372 0.3058256
#> 2 0.2863642 0.3405070
#> 3 0.2755169 0.3169983
#> 4 0.2923392 0.3393765
#> 5 0.2798674 0.3427608
#> 6 0.2918567 0.3089724
#> GO_FATTY_ACID_DERIVATIVE_TRANSPORT GO_FATTY_ACID_ELONGATION
#> 1 0.1596456 0.2804979
#> 2 0.2010166 0.3125196
#> 3 0.1708556 0.2861788
#> 4 0.2441788 0.3264668
#> 5 0.2139327 0.2827284
#> 6 0.1912063 0.3615370
#> GO_FATTY_ACID_HOMEOSTASIS GO_FATTY_ACID_METABOLIC_PROCESS
#> 1 0.3671415 0.2577359
#> 2 0.3652419 0.2826147
#> 3 0.3088938 0.2696712
#> 4 0.3558028 0.2919406
#> 5 0.3914513 0.2863907
#> 6 0.3365161 0.2727220
#> GO_FATTY_ACID_TRANSPORT GO_LONG_CHAIN_FATTY_ACID_TRANSPORT
#> 1 0.2371762 0.2332637
#> 2 0.2762025 0.2659730
#> 3 0.2413611 0.2367156
#> 4 0.2918416 0.2895653
#> 5 0.2806360 0.2793999
#> 6 0.2566789 0.2448035
#> GO_OXIDATIVE_DEMETHYLATION GO_OXIDATIVE_PHOSPHORYLATION
#> 1 0.2169408 0.4612071
#> 2 0.2148223 0.4674767
#> 3 0.2276202 0.4632573
#> 4 0.2541820 0.4676440
#> 5 0.2274789 0.4564732
#> 6 0.2048117 0.4570018
#> GO_RESPONSE_TO_CORTICOSTEROID GO_RESPONSE_TO_FATTY_ACID
#> 1 0.2442545 0.2623077
#> 2 0.2778867 0.3070711
#> 3 0.2559584 0.2752298
#> 4 0.2870169 0.3097421
#> 5 0.2618646 0.2838975
#> 6 0.2749266 0.3027067
#> GO_RESPONSE_TO_OXIDATIVE_STRESS GO_RESPONSE_TO_STEROID_HORMONE
#> 1 0.3273282 0.2638012
#> 2 0.3464181 0.2894555
#> 3 0.3396467 0.2711417
#> 4 0.3548790 0.2981403
#> 5 0.3369893 0.2787726
#> 6 0.3549818 0.2887969
#> GO_REVERSE_CHOLESTEROL_TRANSPORT GO_STEROID_BIOSYNTHETIC_PROCESS
#> 1 0.1688236 0.2539294
#> 2 0.1973852 0.2407076
#> 3 0.1774946 0.2518840
#> 4 0.2096823 0.2607342
#> 5 0.1995360 0.2762403
#> 6 0.2956897 0.2373382
#> GO_STEROID_CATABOLIC_PROCESS GO_STEROID_METABOLIC_PROCESS
#> 1 0.1132707 0.2256655
#> 2 0.1519800 0.2315365
#> 3 0.1234176 0.2337328
#> 4 0.1174818 0.2598273
#> 5 0.1632454 0.2528608
#> 6 0.1603681 0.2273840
#> GO_CD40_RECEPTOR_COMPLEX GO_FATTY_ACID_BINDING GO_FATTY_ACID_LIGASE_ACTIVITY
#> 1 0.3292859 0.3073276 0.2142230
#> 2 0.3247523 0.3381945 0.2374756
#> 3 0.3651546 0.2855470 0.2540963
#> 4 0.3467308 0.3662388 0.2128277
#> 5 0.3467265 0.3326392 0.2670923
#> 6 0.3489275 0.3358139 0.2354773
#> GO_FATTY_ACID_TRANSPORTER_ACTIVITY GO_LONG_CHAIN_FATTY_ACID_BINDING
#> 1 0.2272095 0.3562633
#> 2 0.2843946 0.3459112
#> 3 0.2158170 0.3423470
#> 4 0.2793256 0.4032107
#> 5 0.2835348 0.3507316
#> 6 0.2587235 0.3765035
#> GO_STEROID_BINDING GO_STEROID_DEHYDROGENASE_ACTIVITY
#> 1 0.1878746 0.2408910
#> 2 0.2142008 0.2528208
#> 3 0.2106876 0.2467376
#> 4 0.2524237 0.2585027
#> 5 0.2252652 0.2604061
#> 6 0.2249055 0.2471814
#> GO_STEROID_HYDROXYLASE_ACTIVITY KEGG_FATTY_ACID_METABOLISM
#> 1 0.031346210 0.2938863
#> 2 0.025119372 0.3417113
#> 3 -0.001345972 0.3202046
#> 4 0.093922791 0.3553473
#> 5 0.075164650 0.3313221
#> 6 0.011519790 0.2942114
#> KEGG_GLYCOLYSIS_GLUCONEOGENESIS KEGG_OXIDATIVE_PHOSPHORYLATION
#> 1 0.2951567 0.4208288
#> 2 0.3036129 0.4180549
#> 3 0.3061195 0.4179883
#> 4 0.3365958 0.4204975
#> 5 0.3219235 0.4215568
#> 6 0.2875322 0.4102039
#> KEGG_STEROID_BIOSYNTHESIS KEGG_STEROID_HORMONE_BIOSYNTHESIS
#> 1 0.3941101 0.04251579
#> 2 0.3123473 0.05266150
#> 3 0.3858830 0.07239880
#> 4 0.3607280 0.10926975
#> 5 0.4141288 0.10779772
#> 6 0.3338286 0.03562970
#> REACTOME_CHOLESTEROL_BIOSYNTHESIS REACTOME_DOWNSTREAM_TCR_SIGNALING
#> 1 0.4106553 0.3215812
#> 2 0.3430345 0.3492980
#> 3 0.4169685 0.3750708
#> 4 0.3890932 0.3506583
#> 5 0.4293728 0.3155569
#> 6 0.3641783 0.4032459
#> REACTOME_GLYCOLYSIS REACTOME_STEROID_HORMONES REACTOME_TCR_SIGNALING
#> 1 0.3573611 -0.01776656 0.3097899
#> 2 0.3881147 0.02995596 0.3513332
#> 3 0.3995041 0.03790837 0.3697807
#> 4 0.3956391 0.04737506 0.3433916
#> 5 0.3799740 0.01829576 0.3086881
#> 6 0.3570783 0.04300950 0.4014440